[The effect of DPT and BCG
vaccinations on atopic disorders]
[Article in
Japanese]
Yoneyama H, Suzuki M, Fujii K, Odajima
Y.
Department of Pediatrics, Tokyo Metropolitan Government
Hiroo General Hospital.
METHODS: To examine the relationship
between DPT and BCG vaccinations and development of atopic diseases, we
studied on 143 children resident of the island of Kodushima, Tokyo
Japan. This study dealt with the entire population of 0-3 years old
(82), all of the first graders of the elementary school (31) and all of
the first graders of the junior high school (30) on the Island. RESULTS:
Among the 82 children aged 0-3, out of the 39 who received DPT
vaccination, 10 (25.6%) suffered from bronchial asthma and this ratio
was significantly higher than among the children who have not received
DPT vaccination (1 in 43, 2.3%), (p < 0.01). This was also the case
concerning atopic dermatitis (7 in 39, 18.0% vs 1 in 43, 2.3%) (p <
0.05). The same trend was also observed if three diseases (bronchial
asthma, allergic rhinitis and atopic dermatitis) were combined (22 in
39, 56.4% vs 4 in 43, 9.3%) (p < 0.01). As to the context of BCG
vaccination, there were no cases with atopic disorders among the
tuberculin positive first graders of the elementary school. No such
relations, however, were observed among the first graders of the junior
high school at all. FINDINGS: From these results, we conclude that DPT
vaccination has some effect in the promotion of atopic disorders, while
successful BCG vaccination inhibits the development of atopic disorders,
although the preventive effect of BCG may not last for many
years.