Abs Immunol Allergy Clin North Am. 2003 23(4) 635-48
Immunization of egg-allergic
individuals with egg- or chicken-derived
vaccines.
Kelso JM, Yunginger
JW.
Allergy Division, Naval Medical Center San Diego, CA
92134-5000, USA. JMKelso@nmcsd.med.navy.mil
Viruses used in
several vaccines are propagated in embryonated eggs. These vaccines
contain variable quantities of residual egg or chicken proteins and pose
risks when administered to egg- or chicken-sensitive persons. This
article highlights differences in how vaccines are prepared, with
emphasis on the quantitation of residual egg-derived protein in each
vaccine. Published reports on the frequency and severity of these
vaccine-induced allergic reactions are reviewed, and an algorithm is
provided for the preimmunization evaluation of egg-sensitive
persons.